Fatty acid synthesis in Escherichia coli and its applications towards the production of fatty acid based biofuels

HJ Janßen, A Steinbüchel - Biotechnology for biofuels, 2014 - Springer
The idea of renewable and regenerative resources has inspired research for more than a
hundred years. Ideally, the only spent energy will replenish itself, like plant material …

Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

KS Hwang, HU Kim, P Charusanti, BØ Palsson… - Biotechnology …, 2014 - Elsevier
Streptomyces species continue to attract attention as a source of novel medicinal
compounds. Despite a long history of studies on these microorganisms, they still have many …

Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces

W Wang, S Li, Z Li, J Zhang, K Fan, G Tan, G Ai… - Nature …, 2020 - nature.com
Pharmaceutically important polyketides such as avermectin are mainly produced as
secondary metabolites during the stationary phase of growth of Streptomyces species in …

Triacylglycerol and wax ester-accumulating machinery in prokaryotes

HM Alvarez - Biochimie, 2016 - Elsevier
Gram negative bacteria as well as Gram positive actinobacteria possess the ability to
accumulate variable amounts of wax esters (WE) and/or triacylglycerols (TAG) under …

The Role of Malic Enzyme on Promoting Total Lipid and Fatty Acid Production in Phaeodactylum tricornutum

BH Zhu, RH Zhang, NN Lv, GP Yang… - Frontiers in plant …, 2018 - frontiersin.org
To verify the function of malic enzyme (ME1), the ME1 gene was endogenously
overexpressed in Phaeodactylum tricornutum. Overexpression of ME1 increased neutral …

Metagenomic and metaproteomic analyses of Accumulibacter phosphatis‐enriched floccular and granular biofilm

JJ Barr, BE Dutilh, CT Skennerton… - Environmental …, 2016 - Wiley Online Library
Biofilms are ubiquitous in nature, forming diverse adherent microbial communities that
perform a plethora of functions. Here we operated two laboratory‐scale sequencing batch …

Expression of genes of the Pho regulon is altered in Streptomyces coelicolor

A Millan-Oropeza, C Henry, C Lejeune, M David… - Scientific Reports, 2020 - nature.com
Most currently used antibiotics originate from Streptomycetes and phosphate limitation is an
important trigger of their biosynthesis. Understanding the molecular processes underpinning …

Identification of glucose kinase‐dependent and‐independent pathways for carbon control of primary metabolism, development and antibiotic production in S …

J Gubbens, M Janus, BI Florea… - Molecular …, 2012 - Wiley Online Library
Members of the soil‐dwelling prokaryotic genus S treptomyces are indispensable for the
recycling of complex polysaccharides, and produce a wide range of natural products …

Different impacts of short-chain fatty acids on saturated and polyunsaturated fatty acid biosynthesis in Aurantiochytrium sp. SD116

X Song, Y Tan, Y Liu, J Zhang, G Liu… - Journal of agricultural …, 2013 - ACS Publications
Aurantiochytrium is an important docosahexaenoic acid (DHA) producer containing two
kinds of fatty acid synthesis pathways, that is, the fatty acid synthase pathway (FAS) for …

Enzyme-constrained models and omics analysis of Streptomyces coelicolor reveal metabolic changes that enhance heterologous production

S Sulheim, T Kumelj, D van Dissel… - Iscience, 2020 - cell.com
Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their
genetic potential, including silent and metagenomic BGCs. Although the engineered …