Steroid sulfation and desulfation are fundamental pathways vital for a functional vertebrate
endocrine system. After biosynthesis, hydrophobic steroids are sulfated to expedite …

In hormone-dependent organs, sex hormones and dysregulated hormone signaling have
well-documented roles in cancers of the breast and female reproductive organs including …

Simple Summary While the intratumor microbiome has been largely unexplored in relation
to prostate cancer development, our research shows that microbes may play an anti-tumor …

Rapid (nongenomic) membrane-initiated androgen actions have been described in nuclear
androgen receptor–null cells. Four distinct proteins have been proposed as membrane …

Rapid, cell surface-initiated, pregenomic androgen actions have been described in various
vertebrate cells, but the receptors mediating these actions remain unidentified. We report …

The loss of muscle mass and strength with aging, referred to as sarcopenia, is a prevalent
condition among the elderly. Although the molecular mechanisms underlying sarcopenia …

Significant disparities exist between genders for the development and progression of
several gastro-intestinal (GI) diseases including cancer. Differences in incidence between …

The colon is the largest hormonally active tissue in the human body. It has been known for
over a hundred years that various hormones and bioactive peptides play important roles in …

To understand the androgen receptor (AR) in different human malignancies, we conducted a
pan-cancer analysis of AR in different tumor tissues and association with patient survival …

Abstract Serum-and-glucocorticoid-inducible-kinase-1 (SGK1) is under regulation of several
hormones, mediators and cell stressors. More specifically, SGK1 expression is particularly …