Pathogenesis of leptospirosis: the influence of genomics
Leptospirosis is the most widespread zoonosis worldwide and is caused by serovars of
pathogenic Leptospira species. The understanding of leptospiral pathogenesis lags far …
pathogenic Leptospira species. The understanding of leptospiral pathogenesis lags far …
Leptospiral pathogenomics
Leptospirosis, caused by pathogenic spirochetes belonging to the genus Leptospira, is a
zoonosis with important impacts on human and animal health worldwide. Research on the …
zoonosis with important impacts on human and animal health worldwide. Research on the …
Modeling seasonal leptospirosis transmission and its association with rainfall and temperature in Thailand using time–series and ARIMAX analyses
OBJECTIVE: To study the number of leptospirosis cases in relations to the seasonal pattern,
and its association with climate factors. METHODS: Time series analysis was used to study …
and its association with climate factors. METHODS: Time series analysis was used to study …
Leptospiral hemolysins induce proinflammatory cytokines through Toll-like receptor 2-and 4-mediated JNK and NF-κB signaling pathways
Background Infection with pathogenic Leptospira species causes serious systemic
inflammation in patients. Although a few leptospiral proinflammatory molecules have been …
inflammation in patients. Although a few leptospiral proinflammatory molecules have been …
A Model System for Studying the Transcriptomic and Physiological Changes Associated with Mammalian Host-Adaptation by Leptospira interrogans Serovar …
MJ Caimano, SK Sivasankaran, A Allard… - PLoS …, 2014 - journals.plos.org
Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by
spirochetes belonging to the genus Leptospira. More than 500,000 cases of severe …
spirochetes belonging to the genus Leptospira. More than 500,000 cases of severe …
Histones and histone variant families in prokaryotes
Histones are important chromatin-organizing proteins in eukaryotes and archaea. They form
superhelical structures around which DNA is wrapped. Recent studies have shown that …
superhelical structures around which DNA is wrapped. Recent studies have shown that …
Leptospira interrogans Catalase Is Required for Resistance to H2O2 and for Virulence
Pathogenic Leptospira spp. are likely to encounter higher concentrations of reactive oxygen
species induced by the host innate immune response. In this study, we characterized …
species induced by the host innate immune response. In this study, we characterized …
The lipoprotein LipL32, an enigma of leptospiral biology
GL Murray - Veterinary microbiology, 2013 - Elsevier
Spirochetes of the genus Leptospira are responsible for the widespread, but neglected,
zoonotic disease leptospirosis. In recent years there have been major advances in the …
zoonotic disease leptospirosis. In recent years there have been major advances in the …
Leptospiral structure, physiology, and metabolism
CE Cameron - Leptospira and Leptospirosis, 2015 - Springer
Members of the family Leptospiraceae are thin, spiral, highly motile bacteria that are best
visualized by darkfield microscopy. These characteristics are shared with other members of …
visualized by darkfield microscopy. These characteristics are shared with other members of …
The mammalian cell entry (Mce) protein of pathogenic Leptospira species is responsible for RGD motif‐dependent infection of cells and animals
L Zhang, C Zhang, DM Ojcius, D Sun… - Molecular …, 2012 - Wiley Online Library
Mammalian cell entry proteins (Mces) contribute to Mycobacterium tuberculosis virulence. A
mce homologue has been identified in the Leptospira interrogans genome, but its function …
mce homologue has been identified in the Leptospira interrogans genome, but its function …