This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Highlights•Cyclotides are disulfide-rich macrocyclic peptides from plants that are ultra-
stable.•They are ribosomally synthesized via precursors containing N-terminal and C …

Host defence peptides (HDPs) are antimicrobial agents produced by organisms across the
prokaryotic and eukaryotic kingdoms. Many prokaryotes produce HDPs, which utilise lipid …

Anionic antimicrobial peptides (AAMPs) have been identified in a wide variety of plant
species with net charges that range between− 1 and− 7 and structures that include …

Cyclotides are plant‐derived peptides of approximately 30 amino acids that have the
characteristic structural features of a head‐to‐tail cyclized backbone and a cystine knot …

Cyclotides are true gene products characterized by the presence of six conserved cysteine
residues and knotted arrangement of three disulfide bonds. These macrocyclic peptides …

Viola odorata L., known for its pharmacological properties, produces a plethora of
structurally stable peptides called cyclotides. Cyclotides are macrocyclic peptides with a …

It is becoming increasingly clear that plants ranging across the plant kingdom produce
anionic host defence peptides (AHDPs) with potent activity against a wide variety of human …

En los últimos años, se ha presentado un gran interés en el estudio de especies que
contienen ciclótidos entre sus metabolitos secundarios, los ciclótidos son oligopéptidos …

This chapter provides an overview of methods for the analysis of cyclotides, a structurally
unique class of plant defense peptides. These peptides have been extensively analyzed …