Breast cancer is a complex disease encompassing multiple tumor entities, each
characterized by distinct morphology, behavior and clinical implications. Besides estrogen …

Current standard-of-care (SOC) therapy for breast cancer includes targeted therapies such
as endocrine therapy for estrogen receptor-alpha (ERα) positive; anti-HER2 monoclonal …

Breast cancer is the most frequent invasive tumor diagnosed in women, causing over 400
000 deaths yearly worldwide. Like other tumors, it is a disease with a complex …

Sexual dimorphisms are responsible for profound metabolic differences in health and
behavior. Whether males and females react differently to environmental cues, such as solar …

Tumor suppressor p53 maintains genome stability by regulating diverse cellular functions
including cell cycle arrest, apoptosis, senescence and metabolic homeostasis. Mutations in …

p53 Reactivation and induction of massive apoptosis (PRIMA-1) is a small-molecule
compound that reactivates mutant p53, restoring its normal tumor suppressor function …

More than two-thirds of breast cancers express the estrogen receptor (ER) and depend on
estrogen for growth and survival. Therapies targeting ER function, including aromatase …

Thyroid cancer occurs three times more frequently in females than in males, and in females
the incidence decreases after menopause. This gender difference suggests that the growth …

Antiepileptic drugs (AEDs) are frequently used to treat seizures in glioma patients. AEDs
may have an unrecognized impact in modulating O 6-methylguanine-DNA …

Estrogen receptor α (ERα) plays an important role in the onset and progression of breast
cancer, whereas p53 functions as a major tumor suppressor. We previously reported that …