Direct interactions between proteins are essential for the regulation of their functions in
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …

Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …

Highlights•A thorough review of 14-3-3 protein function.•Discussion of 14-3-3 proteins in
health, disease, and animal models.•Review of 14-3-3 protein-targeted compounds …

Small molecules that modulate the 14-3-3 protein–protein interaction (PPI) network
represent valuable therapeutics and tool compounds. However, access has been lost to 14 …

ABSTRACT Background Protein-protein interactions (PPIs) are intriguing targets for
designing novel small-molecule inhibitors. The role of PPIs in various infectious and …

The stabilization of protein–protein interactions (PPIs) has emerged as a promising strategy
in chemical biology and drug discovery. The identification of suitable starting points for …

Dysregulation of protein–protein interactions (PPIs) commonly leads to disease. PPI
stabilization has only recently been systematically explored for drug discovery despite being …

The protein K-Ras functions as a molecular switch in signaling pathways regulating cell
growth. In the human mitogen-activated protein kinase (MAPK) pathway, which is implicated …

3-3s represent a family of highly conserved 30 kDa acidic proteins. 14-3-3s recognize and
bind specific phospho-sequences on client partners and operate as molecular hubs to …