Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Chromatin plays a crucial role in genome compaction and is fundamental for regulating
multiple nuclear processes. Nucleosomes, the basic building blocks of chromatin, are …

The mobility of transposable elements (TEs) contributes to evolution of genomes. Their
uncontrolled activity causes genomic instability; therefore, expression of TEs is silenced by …

Eukaryotes have a multitude of diverse mechanisms for organising and using their
genomes, but the histones that make up chromatin are highly conserved. Unusually …

In this hypothesis article, we explore the origin of the eukaryotic nucleus. In doing so, we first
look afresh at the nature of this defining feature of the eukaryotic cell and its core functions …

5-Methylcytosine (5mC) is a widespread silencing mechanism that controls genomic
parasites. In eukaryotes, 5mC has gained complex roles in gene regulation beyond parasite …

Ichthyosporea is an underexplored group of unicellular eukaryotes closely related to
animals. Thanks to their phylogenetic position, genomic content, and development through a …

Polycomb group proteins, as part of the Polycomb repressive complexes, are essential in
gene repression through chromatin compaction by canonical PRC1, mono-ubiquitylation of …

Chronic kidney disease (CKD) affects> 10% of the world population, with increasing
prevalence in middle age. The risk for CKD is dependent on the number of functioning …

Facultative heterochromatin controls development and differentiation in many eukaryotes. In
metazoans, plants, and many filamentous fungi, facultative heterochromatin is characterized …