Increasing evidence indicates that chromatin modifications are important regulators of
mammalian telomeres. Telomeres provide well studied paradigms of heterochromatin …

Heterochromatin protein 1 (HP1) proteins were originally identified as critical components in
heterochromatin-mediated gene silencing and are now recognized to play essential roles in …

Double-strand breaks (DSBs) in heterochromatic repetitive DNAs pose significant threats to
genome integrity, but information about how such lesions are processed and repaired is …

Telomere-repeat-encoding RNA (referred to as TERRA) has been identified as a potential
component of yeast and mammalian telomeres. We show here that TERRA RNA interacts …

Silencing of transposons in the Drosophila ovary relies on three Piwi family proteins—Piwi,
Aubergine (Aub), and Ago3—acting in concert with their small RNA guides, the Piwi …

Fungal secondary metabolites are important bioactive compounds but the conditions
leading to expression of most of the putative secondary metabolism (SM) genes predicted by …

Gene silencing by the repressive telomeric chromatin environment, referred to as telomere
position effect (TPE), has been well characterized in yeast and depends on telomere length …

Transposable elements (TEs) are ubiquitous genetic elements, able to jump from one
location of the genome to another, in all organisms. For this reason, on the one hand, TEs …

Protection of chromosome ends from DNA repair and degradation activities is mediated by
specialized protein complexes bound to telomere repeats. Recently, it has become apparent …

HP1 proteins are a highly conserved family of eukaryotic proteins that bind to methylated
histone H3 lysine 9 (H3K9) and are required for heterochromatic gene silencing. In fission …