The family of matrix metalloproteinases (MMPs) consists of a set of biological targets that are
involved in a multitude of severe pathogenic events such as different forms of cancers or …

Critical for diverse biological processes, proteases represent one of the largest families of
pharmaceutical targets. To inhibit pathogenic proteases with desired selectivity, monoclonal …

Solid tumors are inherently difficult to treat because of large regions of hypoxia and are often
chemotherapy-or radiotherapy-resistant. It seems that cancer stem cells reside in hypoxic …

Macromolecular protease inhibitors and camelid single-domain antibodies achieve their
enzymic inhibition functions often through protruded structures that directly interact with …

Background: Proteases are one of the largest pharmaceutical targets for drug developments.
Their dysregulations result in a wide variety of diseases. Because proteolytic networks …

Among influenza A group 1 viruses, those with the haemagglutinin (HA) subtypes H1, H2,
H5 and H9 are considered to pose the greatest pandemic risk. The alpaca-derived single …

Certain embodiments provide isolated anti-MMP-14 antibodies or fragments thereof,
isolated anti-MMP-12 antibodies or fragments thereof, isolated anti-BACE-1 antibodies or …

The aim of this thesis was to combine computational and experimental methods to engineer
high affinity gluten pMHC specific antibodies, validate them, and use them to study peptide …