Endogenous and exogenous sources cause free radical-induced DNA damage in living
organisms by a variety of mechanisms. The highly reactive hydroxyl radical reacts with the …

Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a
propensity for increased levels following toxic insult. Although more than 20 base lesions …

The generation of reactive oxygen species may be both beneficial to cells, performing a
function in inter-and intracellular signalling, and detrimental, modifying cellular …

Free radicals are produced in cells by cellular metabolism and by exogenous agents. These
species react with biomolecules in cells, including DNA. The resulting damage to DNA …

Activities of fast growing human population are altering freshwater ecosystems, endangering
their inhabitants and public health. Organic and trace compounds have a high potential for …

Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …

Endogenous and exogenous sources cause oxidatively induced DNA damage in living
organisms by a variety of mechanisms. The resulting DNA lesions are mutagenic and …

Oxidative DNA damage is a major cause of cell death and mutagenesis in all aerobic
organisms, and several new oxidative base lesions have been identified in recent years …

Oxidative DNA damage has been implicated in mutagenesis, carcinogenesis and aging.
Endogenous cellular processes such as aerobic metabolism generate reactive oxygen …

The most common base substitution arising from oxidative damage of DNA is a GC→ AT
transition. In an effort to determine the oxidized lesion (s) that gives rise to this mutation, the …