It has been known for decades that it is possible to detect small amounts of extracellular
nucleic acids in plasma and serum of healthy and diseased human beings. The unequivocal …

Diagnosing and screening for tumors through noninvasive means represent an important
paradigm shift in precision medicine. In contrast to tissue biopsy, detection of circulating …

Background: Several recent reports have described the detection of circulating, cancer-
related RNA molecules in serum or plasma from cancer patients, but little is known about the …

Early detection of tumor DNA in serum/plasma prior to the development of recurrence or
metastases could help improve the outcome of patients with colorectal cancer (CRC) after …

It is well known that malignant cells circulate in the bloodstream of patients with solid tumors.
However, the biological significance of circulating tumor cells (CTCs) and the clinical …

Colon cancer afflicts more than 135,000 patients per year in America. It kills more than
55,000 patients per year [1] and many more patients suffer morbidity from curative colon …

OBJECTIVES Colorectal cancer (CRC) is the second leading cause of cancer-related death
in the United States. Endoscopic screening is now in favor and its use is increasing, but …

Current researches have proposed a genetic model for colorectal cancer (CRC), in which
the sequential accumulation of mutations in specific cancer-related genes, including …

Colorectal cancer (CRC) is a significant cause of morbidity and mortality in developed
countries, with both genetic and environmental factors contributing to the etiology and …

Introduction: Screening methods for one of the most frequently diagnosed malignancy,
colorectal cancer (CRC), have limitations. Circulating cell-free nucleic acids (cfNA) hold …