Voltage‐gated calcium channels are essential players in many physiological processes in
excitable cells. There are three main subdivisions of calcium channel, defined by the pore …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Norepinephrine (NE) is a neuromodulator that in multiple ways regulates the activity of
neuronal and non-neuronal cells. NE participates in the rapid modulation of cortical circuits …

Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

Background and Purpose Cannabinoids are a promising therapeutic avenue for chronic
pain. However, clinical trials often fail to report analgesic efficacy of cannabinoids. Inhibition …

Voltage gated calcium channels (Ca2+ channels) are key mediators of depolarization
induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of …

Abstract Ca2+/calmodulin-dependent regulation of voltage-gated CaV1–2 Ca2+ channels
shows extraordinary modes of spatial Ca2+ decoding and channel modulation,,,,,, vital for …

The regulation of presynaptic, voltage-gated calcium channels by activation of heptahelical
G protein-coupled receptors exerts a crucial influence on presynaptic calcium entry and …

GABAB receptors, the most abundant inhibitory G protein–coupled receptors in the
mammalian brain, display pronounced diversity in functional properties, cellular signaling …

Fragile X syndrome (FXS), the most common heritable form of mental retardation, is
characterized by synaptic dysfunction. Synaptic transmission depends critically on …