Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

Until recently, dynein was the least understood of the cytoskeletal motors. However, a wealth
of new structural, mechanistic, and cell biological data is shedding light on how this …

Cytoplasmic dynein is a microtubule motor vital for cellular organization and division. It
functions as a~ 4-megadalton complex containing its cofactor dynactin and a cargo-specific …

Cytoplasmic dynein is the major microtubule minus-end–directed cellular motor. Most
dynein activities require dynactin, but the mechanisms regulating cargo-dependent dynein …

The lissencephaly protein Lis1 has been reported to regulate the mechanical behavior of
cytoplasmic dynein, the primary minus-end-directed microtubule motor. However, the …

Abstract Lissencephaly-1 (Lis1) is a key cofactor for dynein-mediated intracellular transport
towards the minus-ends of microtubules. It remains unclear whether Lis1 serves as an …

Cancer cells' ability to migrate through constricting pores in the tissue matrix is limited by
nuclear stiffness. MT1-MMP contributes to metastasis by widening matrix pores, facilitating …

Lissencephaly ('smooth brain') is a severe brain disease associated with numerous
symptoms, including cognitive impairment, and shortened lifespan. The main causative …

Axonal transport is essential for neuronal survival. This is driven by microtubule motors
including dynein, which transports cargo from the axon tip back to the cell body. This …

The molecular motor cytoplasmic dynein is responsible for most minus-end–directed,
microtubule-based transport in eukaryotic cells. It is especially important in neurons, where …