Ten Years of the Manufacturing Classification System: A review of literature applications and an extension of the framework to continuous manufacture
M Leane, K Pitt, G Reynolds, A Tantuccio… - Pharmaceutical …, 2024 - Taylor & Francis
The MCS initiative was first introduced in 2013. Since then, two MCS papers have been
published: the first proposing a structured approach to consider the impact of drug …
published: the first proposing a structured approach to consider the impact of drug …
Surface modifiers on composite particles for direct compaction
FC Chen, WJ Liu, WF Zhu, LY Yang, JW Zhang, Y Feng… - Pharmaceutics, 2022 - mdpi.com
Direct compaction (DC) is considered to be the most effective method of tablet production.
However, only a small number of the active pharmaceutical ingredients (APIs) can be …
However, only a small number of the active pharmaceutical ingredients (APIs) can be …
Attribute transmission and effects of diluents and granulation liquids on granule properties and tablet quality for high shear wet granulation and tableting process
LF Wang, LJ Zhao, YL Hong, L Shen, X Lin - International Journal of …, 2023 - Elsevier
This study aims to examine (i) the effect of diluent types (lactose monohydrate, corn starch,
and microcrystalline cellulose) and granulation liquids (20% polyvinylpyrrolidone K30, 65 …
and microcrystalline cellulose) and granulation liquids (20% polyvinylpyrrolidone K30, 65 …
Enhanced blend uniformity and flowability of low drug loaded fine API blends via dry coating: The effect of mixing time and excipient size
SS Kim, C Castillo, M Cheikhali, H Darweesh… - International Journal of …, 2023 - Elsevier
Although previous research demonstrated improved flowability, packing, fluidization, etc. of
individual powders via nanoparticle dry coating, none considered its impact on very low …
individual powders via nanoparticle dry coating, none considered its impact on very low …
Improvements on multiple direct compaction properties of three powders prepared from Puerariae Lobatae Radix using surface and texture modification: Comparison …
Y Zhang, J Li, Y Gao, F Wu, Y Hong, L Shen… - International Journal of …, 2022 - Elsevier
It has been reported that hydrophilic nano-silica (N) markedly improved direct compaction
(DC) properties of Zingiberis Rhizoma alcoholic extract. This study aims to examine the …
(DC) properties of Zingiberis Rhizoma alcoholic extract. This study aims to examine the …
Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients
Co-processing (CP) provides superior properties to excipients and has become a reliable
option to facilitated formulation and manufacturing of variety of solid dosage forms …
option to facilitated formulation and manufacturing of variety of solid dosage forms …
Research on the powder classification and the key parameters affecting tablet qualities for direct compaction based on powder functional properties
Y Yu, L Zhao, X Lin, Y Wang, R Du, Y Feng - Advanced Powder …, 2021 - Elsevier
Direct compaction (DC) is the ideal method for tablet production. However, DC requires the
highest quality powder functional properties, such as good flowability, compressibility …
highest quality powder functional properties, such as good flowability, compressibility …
Influence of Formulation Factors, Process Parameters, and Selected Quality Attributes on Carvedilol Release from Roller-Compacted Hypromellose-Based Matrix …
A Dular Vovko, B Hodžić, T Brec, G Hudovornik… - Pharmaceutics, 2022 - mdpi.com
The importance of roller compaction is recently increasing. This study evaluates the
combined effects of formulation factors, process parameters, and selected quality attributes …
combined effects of formulation factors, process parameters, and selected quality attributes …
[HTML][HTML] Modulation of the powder properties of lamotrigine by crystal forms
The mechanical properties of powders determine the ease of manufacture and ultimately the
quality of the oral solid dosage forms. Although poor mechanical properties of an active …
quality of the oral solid dosage forms. Although poor mechanical properties of an active …
A model to simultaneously evaluate the compressibility and compactibility of a powder based on the compression ratio
Y Yu, L Zhao, X Lin, Y Wang, Y Feng - International Journal of …, 2020 - Elsevier
The present study aimed to establish a new model to evaluate the compressibility and
compactibility of materials simultaneously. Eighteen types of pharmaceutical excipients were …
compactibility of materials simultaneously. Eighteen types of pharmaceutical excipients were …