It has been 10 years since the role of a chemokine receptor, CXCR4, in breast cancer
metastasis was first documented. Since then, the field of chemokines and cancer has grown …

Chemokines play a vital role in tumor progression and metastasis. Chemokines are involved
in the growth of many cancers including breast cancer, ovarian cancer, pancreatic cancer …

For the past twenty years, chemokines have emerged as a family of critical mediators of cell
migration during immune surveillance, development, inflammation and cancer progression …

The importance of cancer stem cells (CSCs) in tumor-initiation has been firmly established in
leukemia and recently reported for a variety of solid tumors. However, the role of CSCs in …

The chemokines and their receptors are a superfamily of small secreted molecules that
control the migration of many cell types in the body. Several years ago it became clear that …

The chemokine stroma-derived factor (SDF-1/CXCL12) plays multiple roles in tumor
pathogenesis. It has been demonstrated that CXCL12 promotes tumor growth and …

The chemokine CXCL12 and its receptor CXCR4 are expressed widely in human cancers,
including ovarian cancer, in which they are associated with disease progression at the …

Circulating tumor aggregates exhibit a high metastatic potential and could potentially serve
as an important target for cancer therapies. In this study, we developed a microfluidic model …

The 1990s brought a burst of information regarding the structure, expression pattern, and
role in leukocyte migration and adhesion of chemokines and their receptors. At that time, the …

BACKGROUND: Ferritin has been traditionally considered a cytoplasmic iron storage
protein. However, several studies over the last two decades have reported the nuclear …