Despite their diverse biochemical characteristics and functions, all DNA-binding proteins
share the ability to accurately locate their target sites among the vast excess of non-target …

Visualizing and quantifying molecular motion and interactions inside living cells provides
crucial insight into the mechanisms underlying cell function. This has been achieved by …

DNA mismatch repair (MMR), the guardian of the genome, commences when MutS identifies
a mismatch and recruits MutL to nick the error-containing strand, allowing excision and DNA …

A series of novel unique structural organophosphorus aminopyrimidines were developed as
potential DNA-targeting membrane active inhibitors through an efficient one-pot procedure …

Genomes are constantly in flux, undergoing changes due to recombination, repair and
mutagenesis. In vivo, many of such changes are studies using reporters for specific types of …

Helicases involved in genomic maintenance are a class of nucleic-acid dependent ATPases
that convert the energy of ATP hydrolysis into physical work to execute irreversible steps in …

Abstract 3D single-molecule tracking microscopy has enabled measurements of protein
diffusion in living cells, offering information about protein dynamics and cellular …

The ability to detect individual fluorescent molecules inside living cells has enabled a range
of powerful microscopy techniques that resolve biological processes on the molecular scale …

Understanding how multiprotein complexes function in cells requires detailed quantitative
understanding of their association and dissociation kinetics. Analysis of the heterogeneity of …

DNA replication in cells occurs on crowded and often damaged template DNA, forming
potentially deleterious roadblocks to the progressing replication fork. Numerous tools have …