Biosensors integrated 3D organoid/organ-on-a-chip system: A real-time biomechanical, biophysical, and biochemical monitoring and characterization
As a full-fidelity simulation of human cells, tissues, organs, and even systems at the
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …
3D bioprinting strategies, challenges, and opportunities to model the lung tissue microenvironment and its function
M Barreiro Carpio, M Dabaghi, J Ungureanu… - … in Bioengineering and …, 2021 - frontiersin.org
Human lungs are organs with an intricate hierarchical structure and complex composition;
lungs also present heterogeneous mechanical properties that impose dynamic stress on …
lungs also present heterogeneous mechanical properties that impose dynamic stress on …
Real‐Time Measurement of Cell Mechanics as a Clinically Relevant Readout of an In Vitro Lung Fibrosis Model Established on a Bioinspired Basement Membrane
Lung fibrosis, one of the major post‐COVID complications, is a progressive and ultimately
fatal disease without a cure. Here, an organ‐and disease‐specific in vitro mini‐lung fibrosis …
fatal disease without a cure. Here, an organ‐and disease‐specific in vitro mini‐lung fibrosis …
A Bioinspired in vitro Lung Model to Study Particokinetics of Nano-/Microparticles Under Cyclic Stretch and Air-Liquid Interface Conditions
Evolution has endowed the lung with exceptional design providing a large surface area for
gas exchange area (ca. 100 m2) in a relatively small tissue volume (ca. 6 L). This is possible …
gas exchange area (ca. 100 m2) in a relatively small tissue volume (ca. 6 L). This is possible …
Biomimetic in vitro lung models: current challenges and future perspective
As post‐COVID complications, chronic respiratory diseases are one of the foremost causes
of mortality. The quest for a cure for this recent global challenge underlines that the lack of …
of mortality. The quest for a cure for this recent global challenge underlines that the lack of …
Breathing in vitro: Designs and applications of engineered lung models
R Nossa, J Costa, L Cacopardo… - Journal of tissue …, 2021 - journals.sagepub.com
The aim of this review is to provide a systematic design guideline to users, particularly
engineers interested in developing and deploying lung models, and biologists seeking to …
engineers interested in developing and deploying lung models, and biologists seeking to …
Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics
A Artzy-Schnirman, SA Raviv, OD Flikshtain… - Advanced drug delivery …, 2021 - Elsevier
Over the past years, advanced in vitro pulmonary platforms have witnessed exciting
developments that are pushing beyond traditional preclinical cell culture methods. Here, we …
developments that are pushing beyond traditional preclinical cell culture methods. Here, we …
A biomimetic, copolymeric membrane for cell‐stretch experiments with pulmonary epithelial cells at the air‐liquid interface
Chronic respiratory diseases are among the leading causes of death worldwide, but only
symptomatic therapies are available for terminal illness. This in part reflects a lack of …
symptomatic therapies are available for terminal illness. This in part reflects a lack of …
Advanced in vitro lung models for drug and toxicity screening: the promising role of induced pluripotent stem cells
The substantial socioeconomic burden of lung diseases, recently highlighted by the
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …
Plasticizer and catalyst co-functionalized PEDOT: PSS enables stretchable electrochemical sensing of living cells
J Yan, Y Qin, WT Fan, WT Wu, SW Lv, LP Yan… - Chemical …, 2021 - pubs.rsc.org
Recently, stretchable electrochemical sensors have stood out as a powerful tool for the
detection of soft cells and tissues, since they could perfectly comply with the deformation of …
detection of soft cells and tissues, since they could perfectly comply with the deformation of …