HTRA2/OMI-mediated mitochondrial quality control alters macrophage polarization affecting systemic chronic inflammation

Q Liu, X Yan, Y Yuan, R Li, Y Zhao, J Fu… - International Journal of …, 2024 - mdpi.com
Systemic chronic inflammation (SCI) due to intrinsic immune over-activation is an important
factor in the development of many noninfectious chronic diseases, such as …

Structural basis of substrate recognition and allosteric activation of the proapoptotic mitochondrial HtrA2 protease

EE Aspholm, J Lidman, BM Burmann - Nature Communications, 2024 - nature.com
The mitochondrial serine protease HtrA2 is a human homolog of the Escherichia coli Deg-
proteins exhibiting chaperone and proteolytic roles. HtrA2 is involved in both apoptotic …

[HTML][HTML] Synergism between x-ray crystallography and NMR residual dipolar couplings in characterizing protein dynamics

Y Shen, A Bax - Structural Dynamics, 2023 - pubs.aip.org
The important role of structural dynamics in protein function is widely recognized. Thermal or
B-factors and their anisotropy, seen in x-ray analysis of protein structures, report on the …

α-Synuclein and Mitochondria: Probing the Dynamics of Disordered Membrane-protein Regions Using Solid-State Nuclear Magnetic Resonance

A Gallo, S Mansueto, A Emendato, G Fusco… - JACS Au, 2024 - ACS Publications
The characterization of intrinsically disordered regions (IDRs) in membrane-associated
proteins is of crucial importance to elucidate key biochemical processes, including cellular …

Genetic variations as predictors of dispositional and dyadic empathy—a couple study

M Kaźmierczak, M Rybicka, P Syty - Scientific Reports, 2024 - nature.com
Biological drivers of empathy have been explored in an interdisciplinary manner for
decades. Research that merges the psychological and genetic perspectives of empathy has …

Comparative analysis of canine and human HtrA2 to delineate its role in apoptosis and cancer

SP Mudrale, S Dutta, K Natu, P Chaudhari… - Biochemical …, 2024 - portlandpress.com
Therapeutically, targeting the pro-and anti-apoptotic proteins has been one of the major
approaches behind devising strategies to combat associated diseases. Human high …

The repeating, modular architecture of the htra proteases

M Merski, S Macedo-Ribeiro, RM Wieczorek… - Biomolecules, 2022 - mdpi.com
A conserved, 26-residue sequence [AA (X2)[A/G][G/L](X2) GDV [I/L](X2)[V/L] NGE (X1) V
(X6)] and corresponding structure repeating module were identified within the HtrA protease …

Synergistic Multi-Pronged Interactions Mediate the Effective Inhibition of Alpha-Synuclein Aggregation by the Chaperone HtrA1

P Chinchilla, B Wang, JH Lubin, X Yang, JA Roth… - bioRxiv, 2024 - biorxiv.org
The misfolding, aggregation, and the seeded spread of alpha synuclein (α-Syn) aggregates
are linked to the pathogenesis of various neurodegenerative diseases, including …

Switchable client specificity in a dual functional chaperone coordinates light harvesting complex biogenesis

AR Siegel, G Kroon, PE Wright, S Shan - bioRxiv, 2024 - biorxiv.org
The proper assembly of light harvesting complexes (LHCs) is critical for photosynthesis and
requires the biogenesis of light-harvesting chlorophyll a, b-binding proteins (LHCPs) to be …

Advances in NMR spectroscopy of small molecules in solution

P Nolis - 2023 - books.rsc.org
This book chapter covers relevant articles published in peer-reviewed journals in 2022 in
the field of NMR spectroscopy of small molecules in solution. Articles that appeared in 2022 …