Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view

N Chadha, O Silakari - European Journal of Medicinal Chemistry, 2017 - Elsevier
Indoles constitute extensively explored heterocyclic ring systems with wide range of
applications in pathophysiological conditions that is, cancer, microbial and viral infections …

Plant-based indole alkaloids: A comprehensive overview from a pharmacological perspective

F Omar, AM Tareq, AM Alqahtani, K Dhama… - Molecules, 2021 - mdpi.com
Plant-based indole alkaloids are very rich in pharmacological activities, and the indole
nucleus is considered to contribute greatly to these activities. This review's fundamental …

Targeting mRNA processing as an anticancer strategy

J Desterro, P Bak-Gordon… - Nature Reviews Drug …, 2020 - nature.com
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …

Therapeutic potential of indole alkaloids in respiratory diseases: A comprehensive review

S Mitra, SR Prova, SA Sultana, R Das, F Nainu… - Phytomedicine, 2021 - Elsevier
Background Indole alkaloids are very promising for potential therapeutic purposes and
appear to be particularly effective against respiratory diseases. Several experimental studies …

[图书][B] Studies in natural products chemistry

A Rahman - 2023 - books.google.com
Studies in Natural Products Chemistry, Volume 79 covers the synthesis, testing and
recording of the medicinal properties of natural products, providing cutting-edge accounts of …

Major Bioactive Alkaloids and Biological Activities of Tabernaemontana Species (Apocynaceae)

CM Naidoo, Y Naidoo, YH Dewir, HN Murthy… - Plants, 2021 - mdpi.com
Several species belonging to the genus Tabernaemontana have been well researched and
utilized for their wide-ranging biological activities. A few of the most prominent species …

Some new indole–coumarin hybrids; Synthesis, anticancer and Bcl-2 docking studies

PR Kamath, D Sunil, AA Ajees, KSR Pai, S Das - Bioorganic Chemistry, 2015 - Elsevier
Hybrid molecules have attracted attention for their improved biological activity, selectivity
and lesser side effects profile, distinct from their individual components. In the quest for …

Cudraflavone C induces tumor-specific apoptosis in colorectal cancer cells through inhibition of the phosphoinositide 3-kinase (PI3K)-AKT pathway

HC Soo, FFL Chung, KH Lim, VA Yap, TD Bradshaw… - PLoS …, 2017 - journals.plos.org
Cudraflavone C (Cud C) is a naturally-occurring flavonol with reported anti-proliferative
activities. However, the mechanisms by which Cud C induced cytotoxicity have yet to be fully …

Naturally available nitrogen-containing fused heterocyclics as prospective lead molecules in medicinal chemistry

N Bhardwaj, A Pathania… - Current Traditional …, 2021 - ingentaconnect.com
Heterocyclic compounds constitute one of the largest and most versatile families of organic
compounds. There are many heterocyclic compounds that are being isolated from natural …

Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition

MS Hossan, ZY Chan, HM Collins, FN Shipton… - Cancer letters, 2019 - Elsevier
Natural products possess a significant role in anticancer therapy and many currently-used
anticancer drugs are of natural origin. Cerberin (CR), a cardenolide isolated from the fruit …