The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Enhancing the removal of aggregate-prone toxic proteins is a rational therapeutic strategy
for a number of neurodegenerative diseases, especially Huntington's disease and various …

Autophagy is a catabolic pathway by which misfolded proteins or damaged organelles are
engulfed by autophagosomes and then transported to lysosomes for degradation. Recently …

The factors regulating cellular identity are critical for understanding the transition from health
to disease and responses to therapies. Recent literature suggests that autophagy …

The effective therapeutic treatment and the disease-modifying therapy for spinocerebellar
ataxia type 2 (SCA2)(a progressive hereditary disease caused by an expansion of …

Autophagy (here refers to macroautophagy) is a catabolic pathway by which large protein
aggregates and damaged organelles are first sequestered into a double-membraned …

Introduction: Huntington disease is an autosomal dominant neurodegenerative disorder
which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated …

The mechanistic target of rapamycin complex 2 (mTORC2) controls cell metabolism and
survival in response to environmental inputs. Dysregulation of mTORC2 signaling has been …