The eukaryotic 26S proteasome is a large multisubunit complex that degrades the majority
of proteins in the cell under normal conditions. The 26S proteasome can be divided into two …

The degradation of maternally provided molecules is a very important process during early
embryogenesis. However, the vast majority of studies deals with mRNA degradation and …

Contents Vitrification has been shown to decrease the developmental capacity of
mammalian oocytes, and this is closely associated with the abnormal mRNA expressions of …

Fertilization triggers significant cellular remodeling through the oocyte-to-embryo transition.
In this transition, the ubiquitin-proteasome system and autophagy are essential for the …

In eukaryotic cells, the ubiquitin proteasome system plays important roles in diverse cellular
processes. The 26S proteasome is a large enzyme complex that degrades ubiquitinated …

Abstract Background Developmental pluripotency-associated 3 (Dppa3, also called Stella or
PGC7) is a principal maternal protein specially expressed in pre-implantation embryos …

Background Oocyte components are maternally provided, solely determine oocyte quality,
and coordinately determine embryo quality with zygotic gene expression. During oocyte …

The Hedgehog signalling pathway is evolutionarily highly conserved and essential for
embryonic development of invertebrates and vertebrates. Consequently, impaired …

The proteasome is involved in the regulation of all cellular pathways and consequently plays
a central role in the control of cellular homeostasis. Together with its regulators, it is at the …

The proteasome degradation machinery is essential for a variety of cellular processes
including senescence and T‐cell immunity. Decreased proteasome activity is associated …