ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …

After injury to periodontal tissues, a sequentially phased healing response is initiated that
enables wound closure and partial restoration of tissue structure and function. Wound …

The extracellular matrix (ECM) microenvironment plays a central role in cell migration by
providing physiochemical information that influences overall cell behavior. Much of this …

The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors that
are members of the receptor tyrosine kinase family. Both DDRs bind a number of different …

The leukocyte Fcγ receptor (FcγR)-mediated response is important for the efficacy of
therapeutic antibodies; however, little is known about the role of FcγRs in other cell types …

Activated fibroblasts promote physiological wound repair following tissue injury. However,
dysregulation of fibroblast activation contributes to the development of fibrosis by enhanced …

Summary Discoidin domain receptor 1 (DDR1) is a tyrosine kinase collagen adhesion
receptor that mediates cell migration through association with non-muscle myosin IIA …

Vascular smooth muscle cell (vSMC) is highly plastic as its phenotype can change in
response to mechanical cues inherent to the extracellular matrix (ECM). VSMC may be …

Fibrosis is the result of a wound-healing response that fails to restore normal tissue structure
function. One of the critical hallmarks of fibrosis is disrupted collagen remodeling. In tissue …

Background Despite detailed knowledge about the structure and signaling properties of
individual collagen receptors, much remains to be learned about how these receptors …