DNA has played an early and powerful role in the development of bottom-up
nanotechnologies, not least because of DNA's precise, predictable, and controllable …

To pursue the sensitive and efficient detection of informative biomolecules for bioanalysis
and disease diagnosis, a series of signal amplification techniques have been put forward …

G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine
tetrads. They are frequently used as building blocks and functional elements in fields such …

The main challenge in DNA quadruplex design is to encode a three-dimensional structure
into the primary sequence, despite its multiple, repetitive guanine segments. We identify and …

Guanine (G)-rich DNA or RNA sequences can assemble or intramolecularly fold into G-
quadruplexes formed through the stacking of planar G· G· G· G tetrads in the presence of …

Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the
stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures …

A possible engineering of materials with diverse bio-and nano-applications relies on robust
self-assembly of oligonucleotides. Bottom-up approach utilizing guanine-rich DNA …

With the bloom of DNA nanotechnology, diverse DNA amplification strategies have been
designed and applied in bioassays. Among them, hybridization chain reaction (HCR) is …

We examined the assembly of DNA G-quadruplexes (G4s) into higher-order structures using
atomic force microscopy, optical and electrophoretic methods, NMR spectroscopy and …

The relatively low stability and polymorphism of bimolecular G-quadruplexes (bi-G4s) are
big difficulties that are faced in employing them to guide DNA assembly, as they are usually …