The etiology of preeclampsia

E Jung, R Romero, L Yeo, N Gomez-Lopez… - American journal of …, 2022 - Elsevier
Preeclampsia is one of the “great obstetrical syndromes” in which multiple and sometimes
overlapping pathologic processes activate a common pathway consisting of endothelial cell …

[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

S Rana, SD Burke, SA Karumanchi - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …

Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface

F Yang, Q Zheng, L Jin - Frontiers in immunology, 2019 - frontiersin.org
A successful pregnancy requires a fine-tuned and highly regulated balance between
immune activation and embryonic antigen tolerance. Since the fetus is semi-allogeneic, the …

The unique immunological and microbial aspects of pregnancy

G Mor, P Aldo, AB Alvero - Nature Reviews Immunology, 2017 - nature.com
The comparison of the immunological state of pregnancy to an immunosuppressed host–
graft model continues to lead research and clinical practice to ill-defined approaches. This …

The role of immune cells and mediators in preeclampsia

E Deer, O Herrock, N Campbell, D Cornelius… - Nature Reviews …, 2023 - nature.com
Preeclampsia is a hypertensive disorder of major concern in pregnancy than can lead to
intrauterine growth restriction, placental abruption and stillbirth. The pathophysiology of …

Mechanisms of key innate immune cells in early-and late-onset preeclampsia

I Aneman, D Pienaar, S Suvakov, TP Simic… - Frontiers in …, 2020 - frontiersin.org
Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying
multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized …

Endometrial immune dysfunction in recurrent pregnancy loss

C Ticconi, A Pietropolli, N Di Simone… - International journal of …, 2019 - mdpi.com
Recurrent pregnancy loss (RPL) represents an unresolved problem for contemporary
gynecology and obstetrics. In fact, it is not only a relevant complication of pregnancy, but is …

A microphysiological model of human trophoblast invasion during implantation

JY Park, S Mani, G Clair, HM Olson, VL Paurus… - Nature …, 2022 - nature.com
Successful establishment of pregnancy requires adhesion of an embryo to the endometrium
and subsequent invasion into the maternal tissue. Abnormalities in this critical process of …

NKG2D: a master regulator of immune cell responsiveness

FM Wensveen, V Jelenčić, B Polić - Frontiers in immunology, 2018 - frontiersin.org
NKG2D is an activating receptor that is mostly expressed on cells of the cytotoxic arm of the
immune system. Ligands of NKG2D are normally of low abundance, but can be induced in …

Transplantation of human umbilical cord mesenchymal stem cells to treat premature ovarian failure

O Shareghi-Oskoue, L Aghebati-Maleki… - Stem Cell Research & …, 2021 - Springer
As one of the problems and diseases for women before 40 years, premature ovarian failure
(POF) could be characterized by amenorrhea, low estrogen levels, infertility, high …