[HTML][HTML] MicroRNA-based therapy for glioblastoma: Opportunities and challenges

Q Lei, Y Yang, W Zhou, W Liu, Y Li, N Qi, Q Li… - European Journal of …, 2023 - Elsevier
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor and
is characterized by high mortality and morbidity rates and unpredictable clinical behavior …

Exosomes and micro-RNAs in aging process

Y Hamdan, L Mazini, G Malka - Biomedicines, 2021 - mdpi.com
Exosomes are the main actors of intercellular communications and have gained great
interest in the new cell-free regenerative medicine. These nanoparticles are secreted by …

MiR‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer

R Dinami, L Pompili, E Petti, M Porru… - EMBO Molecular …, 2023 - embopress.org
The telomeric repeat‐binding factor 2 (TRF2) is a telomere‐capping protein that plays a key
role in the maintenance of telomere structure and function. It is highly expressed in different …

Combining single-cell RNA sequencing of peripheral blood mononuclear cells and exosomal transcriptome to reveal the cellular and genetic profiles in COPD

Y Pei, Y Wei, B Peng, M Wang, W Xu, Z Chen, X Ke… - Respiratory …, 2022 - Springer
Background It has been a long-held consensus that immune reactions primarily mediate the
pathology of chronic obstructive pulmonary disease (COPD), and that exosomes may …

A rationally identified panel of microRNAs targets multiple oncogenic pathways to enhance chemotherapeutic effects in glioblastoma models

N Sadeghipour, SU Kumar, TF Massoud… - Scientific Reports, 2022 - nature.com
Glioblastoma (GBM) is the most common malignant brain tumor. Available treatments have
limited success because most patients develop chemoresistance. Alternative strategies are …

Exploring the role of microRNAs in glioma progression, prognosis, and therapeutic strategies

O Tluli, M Al-Maadhadi, AA Al-Khulaifi, AF Akomolafe… - Cancers, 2023 - mdpi.com
Simple Summary Despite advancements in healthcare and research, the occurrence of
gliomas, a type of brain tumor, continues to rise. Emerging evidence has proven that …

Circulating liquid biopsy biomarkers in glioblastoma: Advances and challenges

AA Seyhan - International Journal of Molecular Sciences, 2024 - pmc.ncbi.nlm.nih.gov
Gliomas, particularly glioblastoma (GBM), represent the most prevalent and aggressive
tumors of the central nervous system (CNS). Despite recent treatment advancements, patient …

[HTML][HTML] Advancements in Telomerase-Targeted Therapies for Glioblastoma: A Systematic Review

G Pennisi, P Bruzzaniti, B Burattini… - International Journal of …, 2024 - mdpi.com
Glioblastoma (GBM) is a primary CNS tumor that is highly lethal in adults and has limited
treatment options. Despite advancements in understanding the GBM biology, the standard …

MicroRNAs regulating SOX2 in cancer progression and therapy response

S Mirzaei, H Saebfar, MH Gholami… - Expert reviews in …, 2021 - cambridge.org
The proliferation, metastasis and therapy response of tumour cells are tightly regulated by
interaction among various signalling networks. The microRNAs (miRNAs) can bind to 3 …

New perspective on DNA response pathway (DDR) in glioblastoma, focus on classic biomarkers and emerging roles of ncRNAs

BO Pirlog, S Ilut, R Pirlog, P Chiroi, A Nutu… - Expert Reviews in …, 2023 - cambridge.org
Background Glioblastoma (GBM) is the most frequent type of primary brain cancer, having a
median survival of only 15 months. The current standard of care includes a combination of …