Over the past decade, cross-linking mass spectrometry (CLMS) has developed into a robust
and flexible tool that provides medium-resolution structural information. CLMS data provide …

Highlights•Hybrid-FRET on rails automates FRET-based integrative structural
modeling.•Automated experiment design assures highest structural quality with minimal …

This article reports the outcome of the 12th round of Critical Assessment of Structure
Prediction (CASP12), held in 2016. CASP is a community experiment to determine the state …

Crosslinking mass spectrometry has become a core technology in structural biology and is
expanding its reach towards systems biology. Its appeal lies in a rapid workflow, high …

Observing the structures of proteins within the cell and tracking structural changes under
different cellular conditions are the ultimate challenges for structural biology. This, however …

Knowledge of protein structure is crucial to our understanding of biological function and is
routinely used in drug discovery. High-resolution techniques to determine the three …

Mass spectrometry (MS) has become an indispensable tool for investigating the
architectures and dynamics of macromolecular assemblies. Here we show that covalent …

Sin3/HDAC complexes function by deacetylating histones, condensing chromatin, and
modulating gene expression. Although components used to build these complexes have …

With the advance of experimental procedures obtaining chemical crosslinking information is
becoming a fast and routine practice. Information on crosslinks can greatly enhance the …

Cleavable cross-linkers are gaining increasing importance for chemical cross-linking/mass
spectrometry (MS) as they permit a reliable and automated data analysis in structural studies …