Highlights•Sugar-binding C-type carbohydrate-recognition domains fall in five structural
groups.•Structures for many of these domains, covering all of the groups, have been …

Patients with rheumatoid arthritis (RA) receive highly targeted biologic therapies without
previous knowledge of target expression levels in the diseased tissue. Approximately 40 …

Lectins are a class of proteins responsible for several biological roles such as cell-cell
interactions, signaling pathways, and several innate immune responses against pathogens …

Sialoadhesin (Sn, Siglec-1, CD169) is a member of the sialic acid binding Ig-like lectin
(siglec) family expressed on macrophages. Its macrophage specific expression makes it an …

Mammalian glycan‐binding receptors, sometimes known as lectins, interact with glycans,
the oligosaccharide portions of endogenous mammalian glycoproteins and glycolipids as …

Chronic lymphocytic leukemia (CLL) is a heterogeneous B-cell cancer exhibiting a wide
spectrum of disease courses and treatment responses. Molecular characterization of RNA …

Spleen tyrosine kinase Syk and its substrate SLP65 (also called BLNK) are proximal signal
transducer elements of the B‐cell antigen receptor (BCR). Yet, our understanding of signal …

Introduction Plasmacytoid dendritic cells (pDCs) infiltrate a large set of human cancers.
Interferon alpha (IFN-α) produced by pDCs induces growth arrest and apoptosis in tumor …

Recent studies have focused their attention on conjunctivitis as one of the symptoms of
coronavirus disease 2019 (COVID-19). Therefore, tear samples were taken from COVID-19 …

Siglec-1, also known as Sialoadhesin (Sn) and CD169 is highly conserved among
vertebrates and with 17 immunoglobulin-like domains is Siglec-1 the largest member of the …