Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …

The G-protein-gated inwardly rectifying potassium (Kir3/GIRK) channel is the effector of
many G-protein-coupled receptors (GPCRs). Its dysfunction has been linked to the …

Synaptic plasticity is a cellular process involved in learning and memory by which specific
patterns of neural activity adapt the synaptic strength and efficacy of the synaptic …

Background The amyloid-β (A β) cascade is one of the most studied theories linked to AD. In
multiple models, A β accumulation and dyshomeostasis have shown a key role in AD onset …

Learning and memory occurrence requires of hippocampal long-term synaptic plasticity and
precise neural activity orchestrated by brain network oscillations, both processes …

Prefrontal cortex (PFC)-related functions, such as working memory (WM) and cognitive
flexibility (CF), are among the first to be altered at early stages of Alzheimer's disease (AD) …

The failure to develop analgesic drugs is attributed not only to the complex and diverse
pathophysiology of pain in humans but also to the poor experimental design and poor …

Alzheimer's disease (AD) is a neurodegenerative disease with unelucidated molecular
pathogenesis. Herein, we aimed to identify potential hub genes governing the pathogenesis …