Aminoglycoside (AG) antibiotics are used to treat many Gram-negative and some Gram-
positive infections and, importantly, multidrug-resistant tuberculosis. Among various …

Lipid-based carriers represent the most widely used alternative to viral vectors for gene
expression and gene silencing purposes. This class of non-viral vectors is particularly …

Aminoglycosides are chemically diverse, broad-spectrum antibiotics that target functional
centers within the bacterial ribosome to impact all four principle stages (initiation, elongation …

Hereunder, we highlight bacterial membrane anionic lipids as attractive targets in the design
of antibacterial drugs which can be effective against both Gram-positive and Gram-negative …

Aminoglycosides are a family of naturally isolated or chemically semi‐synthesized
antibiotics consisting of aminocyclitols with several amino and saccharide units. The unique …

Following the discovery of streptomycin from Streptomyces griseus in the 1940s by Selman
Waksman and colleagues, aminoglycosides were first used to treat tuberculosis and then …

Infectious diseases remain significant health concerns worldwide, and resistance is
particularly common in patients with tuberculosis caused by Mycobacterium tuberculosis …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …

In this study, a sensitive fluorescent method is designed to detect tobramycin (TOB) drug
applying a hybrid structure of three aptamer strands and SYBR Green I (SGI) fluorescent dye …

The spread of antibiotic resistance is turning many of the currently used antibiotics less
effective against common infections. To address this public health challenge, it is critical to …