The biogenesis, folding, and structure of α-helical membrane proteins (MPs) are important to
understand because they underlie virtually all physiological processes in cells including key …

The activities of integral membrane proteins are often affected by the structures of the lipid
molecules that surround them in the membrane. One important parameter is the …

The conversion of coarse-grained to atomistic models is an important step in obtaining
insight about atomistic scale processes from coarse-grained simulations. For this process …

Research on the biochemistry and molecular biology of lipids and lipoproteins has
experienced remarkable growth in the past 20 years, particularly with the realization that …

The prion hypothesis posits that a misfolded form of prion protein (PrP) is responsible for the
infectivity of prion disease. Using recombinant murine PrP purified from Escherichia coli, we …

Lipid molecules bound to membrane proteins are resolved in some high-resolution
structures of membrane proteins. An analysis of these structures provides a framework …

Detergents are invaluable tools for studying membrane proteins. However, these
deceptively simple, amphipathic molecules exhibit complex behavior when they self …

The secretory production of recombinant proteins by the Gram-negative bacterium
Escherichia coli has several advantages over intracellular production as inclusion bodies. In …

Bitopic integral membrane proteins with a single transmembrane helix play diverse roles in
catalysis, cell signaling, and morphogenesis. Complete monospanning protein structures …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …