Drug designing and development is an important area of research for pharmaceutical
companies and chemical scientists. However, low efficacy, off-target delivery, time …

The ribosomal protein S27a (RPS27a) is cleaved from the fusion protein ubiquitin–RPS27a
(Ub–RPS27a). Generally, Ub and RPS27a are coexpressed as a fusion protein but function …

The current standard-of-care adjuvant treatment for patients with colorectal cancer (CRC)
comprises a fluoropyrimidine (5-fluorouracil or capecitabine) as a single agent or in …

The FOLFOX scheme, based on the association of 5-fluorouracil and oxaliplatin, is the most
frequently indicated chemotherapy scheme for patients diagnosed with metastatic colorectal …

Colorectal cancer (CRC) is a major health problem with an estimated 1. 8 million new cases
worldwide. To date, most CRC studies have focused on DNA-related aberrations, leaving …

Currently, metastatic colon cancer is treated with monotherapeutic regimens such as folinic
acid, fluorouracil, and oxaliplatin (FOLFOX), capecitabine and oxaliplatin (CapeOX), and …

Breast cancer (BC) is the leading cause of cancer-related death among women and the
most commonly diagnosed cancer worldwide. Although in recent years large-scale efforts …

Breast cancer (BC) is a heterogeneous disease where genomic alterations, protein
expression deregulation, signaling pathway alterations, hormone disruption, ethnicity and …

Many primary-tumor subregions exhibit low levels of molecular oxygen and restricted access
to nutrients due to poor vascularization in the tissue, phenomenon known as hypoxia …

Background: Cyclin-dependent kinase 4 (CDK4) and the human epidermal growth factor
receptor 2 (HER2) are two of the most promising targets in oncology research. Thus, a series …