Role of complement, anti-complement therapeutics, and other targeted immunotherapies in myasthenia gravis
MC Dalakas - Expert Review of Clinical Immunology, 2022 - Taylor & Francis
Introduction Several patients with myasthenia gravis (MG) do not adequately respond to
available drugs or exhibit poor tolerance, necessitating the need for new therapies. Areas …
available drugs or exhibit poor tolerance, necessitating the need for new therapies. Areas …
Safety and efficacy of zilucoplan in patients with generalised myasthenia gravis (RAISE): a randomised, double-blind, placebo-controlled, phase 3 study
JF Howard, S Bresch, A Genge… - The Lancet …, 2023 - thelancet.com
Background Generalised myasthenia gravis is a chronic, unpredictable, and debilitating rare
disease, often accompanied by high treatment burden and with an unmet need for more …
disease, often accompanied by high treatment burden and with an unmet need for more …
Terminal complement inhibitor ravulizumab in generalized myasthenia gravis
Background Generalized myasthenia gravis (gMG) is a rare, chronic, and debilitating
autoimmune disease. Activation of the complement system by autoantibodies against the …
autoimmune disease. Activation of the complement system by autoantibodies against the …
[HTML][HTML] Burden of disease in myasthenia gravis: taking the patient's perspective
S Lehnerer, J Jacobi, R Schilling, U Grittner… - Journal of …, 2022 - Springer
Background Myasthenia gravis (MG) leads to exertion-dependent muscle weakness, but
also psychological and social well-being are limited. We aim to describe the burden of …
also psychological and social well-being are limited. We aim to describe the burden of …
[HTML][HTML] Independent risk factors for myasthenic crisis and disease exacerbation in a retrospective cohort of myasthenia gravis patients
C Nelke, F Stascheit, C Eckert, M Pawlitzki… - Journal of …, 2022 - Springer
Background Myasthenic crisis (MC) and disease exacerbation in myasthenia gravis (MG)
are associated with significant lethality and continue to impose a high disease burden on …
are associated with significant lethality and continue to impose a high disease burden on …
Advances and challenges in the treatment of myasthenia gravis
C Schneider-Gold, NE Gilhus - Therapeutic advances in …, 2021 - journals.sagepub.com
Myasthenia gravis (MG) is a chronic autoimmune disease with fluctuating muscle weakness
and fatigability. Standard immunomodulatory treatment may fail to achieve sufficient …
and fatigability. Standard immunomodulatory treatment may fail to achieve sufficient …
Efficacy of innovative therapies in myasthenia gravis: a systematic review, meta‐analysis and network meta‐analysis
Background and purpose Therapy for myasthenia gravis (MG) is undergoing a profound
change, with new treatments being tested. These include complement inhibitors and …
change, with new treatments being tested. These include complement inhibitors and …
Guideline for the management of myasthenic syndromes
H Wiendl, A Abicht, A Chan… - Therapeutic …, 2023 - journals.sagepub.com
Myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and congenital
myasthenic syndromes (CMS) represent an etiologically heterogeneous group of (very) rare …
myasthenic syndromes (CMS) represent an etiologically heterogeneous group of (very) rare …
[HTML][HTML] Efgartigimod improved health-related quality of life in generalized myasthenia gravis: results from a randomized, double-blind, placebo-controlled, phase 3 …
F Saccà, C Barnett, T Vu, S Peric, GA Phillips… - Journal of …, 2023 - Springer
There are substantial disease and health-related quality-of-life (HRQoL) burdens for many
patients with myasthenia gravis (MG), especially for those whose disease symptoms are not …
patients with myasthenia gravis (MG), especially for those whose disease symptoms are not …