Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

Nicotinic acetylcholine receptors (nAChRs) regulate critical aspects of brain maturation
during the prenatal, early postnatal, and adolescent periods. During these developmental …

A single nicotine exposure increases dopamine levels in the mesolimbic reward system for
hours, but nicotine concentrations experienced by smokers desensitize nAChRs on …

The tragic health effects of nicotine addiction highlight the importance of investigating the
cellular mechanisms of this complex behavioral phenomenon. The chain of cause and effect …

Nicotine, the primary psychoactive component of tobacco smoke, produces diverse
neurophysiological, motivational and behavioural effects through several brain regions and …

Nicotinic acetylcholine receptors (nAChRs) expressed by dopaminergic (DA) neurons have
long been considered as potential therapeutic targets for the treatment of several …

Alzheimer's disease is a complex disorder affecting multiple neurotransmitters. In particular,
the degenerative progression is associated with loss within the cholinergic systems. It …

Although many psychopharmacological factors contribute to nicotine addiction, midbrain
dopaminergic systems have received much attention because of their roles in reinforcement …

Dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area of
the midbrain form the nigrostriatal and mesocorticolimbic dopaminergic pathways that …

Nicotinic ACh receptors (nAChRs) have been implicated in a variety of brain functions,
including neuronal development, learning and memory formation, and reward. Although …