Accumulation of phosphorylated intermediates during cellular metabolism can have wide-
ranging toxic effects on many organisms, including humans and the pathogens that infect …

Chemical preservatives are ubiquitously used to suppress the growth of or kill
microorganisms across numerous industries, including the food industry. Utilizing yeast …

The Candida albicans high-affinity phosphate transporter Pho84 is required for normal
Target of Rapamycin (TOR) signaling, oxidative stress resistance, and virulence of this …

Excessive fructose intake is a risk factor for the development of obesity and its complications.
Targeting ketohexokinase (KHK), the first enzyme of fructose metabolism, has been …

Loss of galactose-1 phosphate uridylyltransferase (GALT) activity in humans results in
Classic Galactosemia, and the GalT-deficient (GalT−/−) mouse mimics the patient condition …

Aluminum (Al) toxicity primarily targets the root tips, inhibiting root growth and function and
leading to crop yield losses on acidic soils. Previously we reported using laser capture …

In the yeast Saccharomyces cerevisiae, trehalose-6-phospahte synthase (Tps1) and
trehalose-6-phosphate phosphatase (Tps2) are the main proteins catalyzing intracellular …

Classic galactosemia is an inborn error of metabolism caused by mutations in the GALT
gene resulting in the diminished activity of the galactose-1-phosphate uridyltransferase …

Plants synthesize a number of different oligomeric or polymeric sugars containing galactose.
During growth and development some of these carbohydrates are metabolized or …

Studying the potency of small-molecules on eukaryotic and prokaryotic cells using
conventional biological settings requires time-consuming procedures and large volumes of …