Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

Gene expression is regulated by transcription factors that work together to read cis-
regulatory DNA sequences. The 'cis-regulatory code'—how cells interpret DNA sequences …

Genetically engineered mouse models (GEMMs) help us to understand human pathologies
and develop new therapies, yet faithfully recapitulating human diseases in mice is …

Investigating how chromatin organization determines cell-type-specific gene expression
remains challenging. Experimental methods for measuring three-dimensional chromatin …

Pervasive transcriptional activity is observed across diverse species. The genomes of extant
organisms have undergone billions of years of evolution, making it unclear whether these …

Careful consideration of how we approach design is crucial to all areas of biotechnology.
However, choosing or developing an effective design methodology is not always easy as …

Background Intramuscular fat (IMF) is closely related to the tenderness, marbling, juiciness,
and flavor of meat. We used a combined transcriptome and metabolome analysis to …

Massively parallel genetic screens have been used to map sequence-to-function
relationships for a variety of genetic elements. However, because these approaches only …

The capability to manipulate and analyze hard-wired metabolic pathways sets the pace at
which we can engineer cellular metabolism. Here, we present a framework to extensively …

Structural variation, such as deletions, duplications, inversions and complex
rearrangements, can have profound effects on gene expression, genome stability …