Claudins are tight junction membrane proteins that are expressed in epithelia and
endothelia and form paracellular barriers and pores that determine tight junction …

Epithelial cells from diverse tissues, including the enterocytes that line the intestinal tract,
remodel their apical surface during differentiation to form a brush border: an array of actin …

INTRODUCTION An intricate balance with our intestinal microbes is pivotal to human health.
A key interface of host-microbial interactions occurs in the mucus that covers the intestinal …

The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus
units. Enterocytes perform the diverse tasks of absorbing a wide range of nutrients while …

The intestinal epithelium is maintained by a population of rapidly cycling (Lgr5+) intestinal
stem cells (ISCs). It has been postulated, however, that slowly cycling ISCs must also be …

Human colonic epithelial cell renewal, proliferation, and differentiation are stringently
controlled by numerous regulatory pathways. To identify genetic programs of human colonic …

Inhibitors of histone deacetylases (HDACs) induce growth arrest, differentiation, and
apoptosis of colon cancer cell lines in vitro and have demonstrated anti-cancer efficacy in …

Colorectal cancers are believed to arise predominantly from adenomas. Although these
precancerous lesions have been subjected to extensive clinical, pathologic, and molecular …

Patients with inflammatory bowel disease (IBD) are susceptible to colitis-associated cancer
(CAC). Chronic inflammation promotes the risk for CAC. In contrast, mucosal healing …

Control of intestinal epithelial stemness is crucial for tissue homeostasis. Disturbances in
epithelial function are implicated in inflammatory and neoplastic diseases of the …