The GBA gene encodes for the lysosomal enzyme glucocerebrosidase (GCase), which
maintains glycosphingolipid homeostasis. Approximately 5–15% of PD patients have …

Sphingolipids, which are components of cellular membranes and organ tissues, can be
synthesized or degraded to modulate cellular responses according to environmental cues …

Dysfunction of the endolysosomal system is implicated in the pathogenesis of both sporadic
and familial Parkinson disease (PD). Variants in genes encoding lysosomal proteins have …

Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Given the clear role of GBA in the pathogenesis of Parkinson's disease (PD) and its impact
on phenotypical characteristics, this review provides an overview of the current knowledge …

The predominantly pre-synaptic intrinsically disordered protein α-synuclein is prone to
misfolding and aggregation in synucleinopathies, such as Parkinson's disease (PD) and …

Abstract α-Synuclein (αSyn) aggregation in Lewy bodies and neurites defines both familial
and 'sporadic'Parkinson's disease. We previously identified α-helically folded αSyn …

Sequence variants or mutations in the GBA gene are numerically the most important risk
factor for Parkinson disease (PD). The GBA gene encodes for the lysosomal hydrolase …

Mutations in the GBA1 gene are the single most frequent genetic risk factor for Parkinson's
disease (PD). Neurodegenerative changes in GBA1-associated PD have been linked to the …

Impaired lipid metabolism is a risk factor for Parkinson's disease (PD) and dementia with
Lewy bodies (DLB) and can shift the physiological α-synuclein (αS) tetramer-monomer (T …