The delivery of antihistaminic agents via the oral route is problematic, especially for elderly
patients. This study aimed to develop a sublingual formulation of promethazine …

Orally dissolving tablets (ODTs) represent one of the recent advances in drug delivery. The
foremost objective of this study was to optimize the utilization of lubricant sodium stearyl …

The therapeutic efficacy of an active ingredients are imperfect owing to the poor solubility
and dissolution rate. Moreover, dissolution is the rate-limiting period towards the absorption …

The bioavailability and therapeutic efficacy of several active molecules is limited due to poor
solubility. Repaglinide is used to lower plasma glucose levels, especially in type II diabetes …

During compatibility study of the AZD7986 project, a peak of 3 area% at the tail (RRT 1.03)
of the active pharmaceutical ingredient (API) was discovered for all tablets containing …

The greatest number of mortality in the world occurred due to hypertension. Several bodily
functions are based on circadian rhythm including hypertension. The stimulation of the …

Recently, the fast disintegrating tablet (FDT) has started gaining popularity and acceptance
as a new drug delivery system. Lubricants could influence on disintegration time (DT) …

Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové Katedra Katedra
farmaceutické technologie Kandidát Mgr. Pavel Ondrejček Školitel prof. PharmDr. Miloslava …

Objective: Lubricants are additives which reduce friction and so essential components of
drug formulation. This piece of work was initiated to evaluate coconut oil as a co-processed …

Orally disintegrating tablets (ODTs) are tablets with medicinal substances, which can rapidly
disintegrate or dissolve in the oral cavity without using water. Their salient immediate …