Microneedles: structure, classification, and application in oral cancer theranostics

X Li, X Xie, Y Wu, Z Zhang, J Liao - Drug Delivery and Translational …, 2023 - Springer
Oral cancer is a malignant tumor that threatens the health of individuals on a global scale.
Currently available clinical treatment methods, including surgery, radiotherapy, and …

Experimental validation of diffraction lithography for fabrication of solid microneedles

JY Tan, Y Li, F Chamani, A Tharzeen, P Prakash… - Materials, 2022 - mdpi.com
Microneedles are highly sought after for medicinal and cosmetic applications. However, the
current manufacturing process for microneedles remains complicated, hindering its …

Ultrasonic plasticization microinjection precision molding of polypropylene microneedle arrays

L Pan, W Wu, J Liu, X Li - ACS Applied Polymer Materials, 2023 - ACS Publications
Ultrasonic plasticization microinjection molding (UPMIM) presents a great application
prospect in the PP microneedle array molding field by virtue of significant reduction of melt …

Comparing the replication fidelity of solid microneedles using injection compression moulding and conventional injection moulding

T Evens, S Castagne, D Seveno, A Van Bael - Micromachines, 2022 - mdpi.com
Polymer surfaces are increasingly being functionalized with micro-and nano-surface
features using mass replication methods such as injection moulding. An example of these …

Producing hollow polymer microneedles using laser ablated molds in an injection molding process

T Evens, L Van Hileghem… - Journal of Micro …, 2021 - asmedigitalcollection.asme.org
Microneedle arrays contain needlelike microscopic structures, which facilitate drug or
vaccine delivery in a minimally invasive way. However, producing hollow microneedles is …

Predicting the replication fidelity of injection molded solid polymer microneedles

T Evens, S Castagne, D Seveno… - International Polymer …, 2022 - degruyter.com
Microneedles are sharp microscopic features, which can be used for drug or vaccine
delivery in a minimally invasive way. Recently, we developed a method to produce polymer …

Design, fabrication, and penetration assessment of polymeric hollow microneedles with different geometries

P Vanwersch, T Evens, A Van Bael… - The International Journal …, 2024 - Springer
Hollow microneedles (HMNs) are minimally invasive needle-like microfeatures usually
arranged in arrays designed for drug delivery and body fluid collection in a painless manner …

Hydroxyethyl methacrylate hydrogel microneedles with high mechanical strength and skin penetration by template method

JJ Huang, TF Cheng, JY Wang - Journal of Polymer Research, 2024 - Springer
This study employed the template method to fabricate microneedle (MN) arrays from
hydroxyethyl methacrylate (HEMA) hydrogel: a high-drug-load pyramid-shaped microneedle …

Demoulding process assessment of elastomers in micro-textured moulds

E Liarte, V Zambrano, LA Gracia, JI Amor… - Open Research …, 2022 - pmc.ncbi.nlm.nih.gov
Background: Micro-texturing is an increasingly used technique that aims at improving the
functional behaviour of components during their useful life, and it is applied in different …

微针在经皮药物递送系统中的应用

赵翰卿, 陈明龙, 卢安琪, 李莹莹, 王清清 - 药学进展, 2024 - pps.cpu.edu.cn
作为经皮给药系统中新兴和高效递送形式的微针, 可以定向突破角质层对药物吸收的限制.
微针具有微创, 无痛, 高适应性和控释药物的优点, 在生物医学经皮给药领域具有广阔的应用前景 …