Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

The TEAD transcription factor family is best known for transcriptional output of the Hippo
signaling pathway and has been implicated in processes such as development, cell growth …

Transcriptional enhanced associate domain (TEAD) transcription factors play important roles
during development, cell proliferation, regeneration, and tissue homeostasis. TEAD …

Lung cancer is one of the most devastating diseases worldwide with high incidence and
mortality. Hippo (Hpo) pathway is a conserved regulator of organ size in both Drosophila …

The Hippo pathway is a critical transcriptional signaling pathway that regulates cell growth,
proliferation and organ development. The transcriptional enhanced associate domain …

TEAD proteins are transcription factors that are crucial for development, but also play a role
in cancers. Several developmentally and pathologically important genes are upregulated by …

The TEAD family of transcription factors is necessary for developmental processes. The
family members contain a TEA domain for the binding with DNA elements and a …

The human TEAD family of transcription factors (TEAD1–4) is required for YAP-mediated
transcription in the Hippo pathway. Hyperactivation of TEAD's co-activator YAP contributes …

Abstract Background Cancer-associated fibroblasts (CAFs) are an important part of the
tumour microenvironment, and their functions are of great concern. This series of …

ABSTRACT Introduction The Hippo pathway represents a new opportunity for the treatment
of cancer. Overexpression of Yes-associated protein (YAP) or transcriptional coactivator with …