Chronic rhinosinusitis (CRS) is a prevalent and heterogeneous disease associated with a
high degree of morbidity. Although there exist specific conditions for diagnosis, it has been …

Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local
inflammation of the upper airways and is historically divided into 2 main phenotypes: CRS …

Background Cystatin SN (CST1) and cystatin SA (CST2) are cysteine protease inhibitors that
protect against allergen, viral, and bacterial proteases. Cystatins are overexpressed in the …

Background Exosomes are secreted epithelial‐derived vesicles that contain a conserved
protein array representative of their parent cell. Exosomes may be reproducibly and …

Chronic rhinosinusitis (CRS) refers to an inflammatory disease of the sinonasal mucosa,
with a significant economic burden and impact on quality of life. The diagnosis of CRS is …

Verapamil is a calcium channel blocker that holds promise for the therapy of chronic
rhinosinusitis (CRS) with and without nasal polyps. The verapamil-induced side effects limit …

Background The coagulation pathway has been previously implicated in the
etiopathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) through analysis of …

Objective P‐glycoprotein (P‐gp) drives type‐2 helper T‐cell inflammation in chronic
rhinosinusitis with nasal polyps (CRSwNP) through unknown posttranslational mechanisms …

Background The fibrinolysis pathway has been previously implicated in the
etiopathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). Objective The …

Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the paranasal sinuses
which represents a significant health burden due to its widespread prevalence and impact …