There are Ca channels in the plasma membrane and also the sarcoplasmic reticulum (SR)
membrane in cardiac myocytes. The relationship between channel structure, associated …

BACKGROUND: Voltage-gated (Cav) Ca2+ channels are multi-subunit complexes that play
diverse roles in a wide variety of tissues. A fundamental mechanism controlling Cav channel …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

A mathematical model of the cardiac ventricular action potential is presented. In our previous
work, the membrane Na+ current and K+ currents were formulated. The present article …

Our aim was to measure the influence of sarcoplasmic reticulum (SR) calcium content ([Ca]
SRT) and free SR [Ca]([Ca] SR) on the fraction of SR calcium released during voltage clamp …

We have developed a mathematical model of the rabbit atrial myocyte and have used it in an
examination of the ionic basis of the atrial action potential. Available biophysical data have …

1. The mechanisms that control release of Ca2+ from the sarcoplasmic reticulum (SR) of
guinea‐pig ventricular cells were studied by observing intracellular calcium concentration …

Many high threshold, voltage-gated Ca 2+ channels, including the dihydropyridine-sensitive
class (L-type), inactivate in response not only to voltage, but also to entry of Ca 2+. Despite …

1 The effect of 17β‐oestradiol on cardiac cell contraction, inward Ca2+ current and
intracellular free Ca2+ ([free Ca2+] i) was investigated in guinea‐pig single, isolated …

The local control theory of excitation-contraction (EC) coupling in cardiac muscle asserts that
L-type Ca 2+ current tightly controls Ca 2+ release from the sarcoplasmic reticulum (SR) via …