The segmentation clock is an oscillating genetic network thought to govern the rhythmic and
sequential subdivision of the elongating body axis of the vertebrate embryo into somites: the …

The body axis of vertebrates is composed of a serial repetition of similar anatomical modules
that are called segments or metameres. This particular mode of organization is especially …

Haematopoietic stem cells (HSCs) are a self-renewing population of cells that continuously
replenish all blood and immune cells during the lifetime of an individual,. HSCs are used …

RNA fluorescence in situ hybridization (FISH) and antibody staining/immunofluorescence
(IF) are widely used to detect distributions of mRNAs and proteins. Here we describe a …

The “segmentation clock” is thought to coordinate sequential segmentation of the body axis
in vertebrate embryos. This clock comprises a multicellular genetic network of synchronized …

During angiogenic sprouting, newly forming blood vessels need to connect to the existing
vasculature in order to establish a functional circulatory loop. Previous studies have …

Periodic somite segmentation in vertebrate embryos is controlled by the 'segmentation
clock', which consists of numerous cellular oscillators. Although the properties of a single …

Mechanosensory hair cells within the zebrafish lateral line spontaneously regenerate after
aminoglycoside-induced death. Exposure of 5-d-old larvae to 400 μm neomycin for 1 h …

The somites of the vertebrate embryo are clocked out sequentially from the presomitic
mesoderm (PSM) at the tail end of the embryo. Formation of each somite corresponds to one …

Background Coupled biological oscillators can tick with the same period. How this collective
period is established is a key question in understanding biological clocks. We explore this …