Recent advance in oxazole-based medicinal chemistry
HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry
Benzothiazole (BTA) and its derivatives are the most important heterocyclic compounds,
which are common and integral feature of a variety of natural products and pharmaceutical …
which are common and integral feature of a variety of natural products and pharmaceutical …
Structure activity relationship (SAR) study of benzimidazole scaffold for different biological activities: A mini-review
G Yadav, S Ganguly - European journal of medicinal chemistry, 2015 - Elsevier
Benzimidazoles are the fused heterocyclic ring systems which form an integral part of
vitamin B 12 and have been luring many researchers all over the world to assess their …
vitamin B 12 and have been luring many researchers all over the world to assess their …
Therapeutic evolution of benzimidazole derivatives in the last quinquennial period
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
New progress in azole compounds as antimicrobial agents
HZ Zhang, LL Gan, H Wang… - Mini reviews in medicinal …, 2017 - ingentaconnect.com
The increasing incidence of microbial resistance and newly emerging pathogens have
become a serious challenge for public health. More and more efforts have been directed to …
become a serious challenge for public health. More and more efforts have been directed to …
Therapeutic advancement of benzothiazole derivatives in the last decennial period
S Tariq, P Kamboj, M Amir - Archiv der Pharmazie, 2019 - Wiley Online Library
Benzothiazole, a fused heterocyclic moiety, has attracted synthetic and medicinal chemists
for good reasons. It is a valuable scaffold that possesses diverse biological activities, such …
for good reasons. It is a valuable scaffold that possesses diverse biological activities, such …
Synthesis, SAR and molecular docking studies of benzo [d] thiazole-hydrazones as potential antibacterial and antifungal agents
GF Zha, J Leng, N Darshini, T Shubhavathi… - Bioorganic & medicinal …, 2017 - Elsevier
A series of new benzo [d] thiazole-hydrazones analogues were synthesized and screened
for their in vitro antibacterial and antifungal activities. The results revealed that compounds …
for their in vitro antibacterial and antifungal activities. The results revealed that compounds …
1, 2, 4-Triazole-based benzothiazole/benzoxazole derivatives: Design, synthesis, p38α MAP kinase inhibition, anti-inflammatory activity and molecular docking studies
Abstract Novel N-(benzothiazol/oxazol-2-yl)-2-[(5-(phenoxymethyl)-4-aryl-4H-1, 2, 4-triazol-3-
yl) thio] acetamide derivatives (5a-n) were synthesized and investigated for in vitro anti …
yl) thio] acetamide derivatives (5a-n) were synthesized and investigated for in vitro anti …
Discovery of novel pyrimidine-based benzothiazole derivatives as potent cyclin-dependent kinase 2 inhibitors with anticancer activity
PC Diao, WY Lin, XE Jian, YH Li, WW You… - European Journal of …, 2019 - Elsevier
To develop novel CDK2 inhibitors as anticancer agents, a series of novel pyrimidine-based
benzothiazole derivatives were designed and synthesized. Initial biological evaluation …
benzothiazole derivatives were designed and synthesized. Initial biological evaluation …
Importance of fluorine in benzazole compounds
Fluorine-containing heterocycles continue to receive considerable attention due to their
unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules …
unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules …