Recent advance in oxazole-based medicinal chemistry

HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry

RS Keri, MR Patil, SA Patil, S Budagumpi - European Journal of Medicinal …, 2015 - Elsevier
Benzothiazole (BTA) and its derivatives are the most important heterocyclic compounds,
which are common and integral feature of a variety of natural products and pharmaceutical …

Structure activity relationship (SAR) study of benzimidazole scaffold for different biological activities: A mini-review

G Yadav, S Ganguly - European journal of medicinal chemistry, 2015 - Elsevier
Benzimidazoles are the fused heterocyclic ring systems which form an integral part of
vitamin B 12 and have been luring many researchers all over the world to assess their …

Therapeutic evolution of benzimidazole derivatives in the last quinquennial period

W Akhtar, MF Khan, G Verma… - European journal of …, 2017 - Elsevier
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …

New progress in azole compounds as antimicrobial agents

HZ Zhang, LL Gan, H Wang… - Mini reviews in medicinal …, 2017 - ingentaconnect.com
The increasing incidence of microbial resistance and newly emerging pathogens have
become a serious challenge for public health. More and more efforts have been directed to …

Therapeutic advancement of benzothiazole derivatives in the last decennial period

S Tariq, P Kamboj, M Amir - Archiv der Pharmazie, 2019 - Wiley Online Library
Benzothiazole, a fused heterocyclic moiety, has attracted synthetic and medicinal chemists
for good reasons. It is a valuable scaffold that possesses diverse biological activities, such …

Synthesis, SAR and molecular docking studies of benzo [d] thiazole-hydrazones as potential antibacterial and antifungal agents

GF Zha, J Leng, N Darshini, T Shubhavathi… - Bioorganic & medicinal …, 2017 - Elsevier
A series of new benzo [d] thiazole-hydrazones analogues were synthesized and screened
for their in vitro antibacterial and antifungal activities. The results revealed that compounds …

1, 2, 4-Triazole-based benzothiazole/benzoxazole derivatives: Design, synthesis, p38α MAP kinase inhibition, anti-inflammatory activity and molecular docking studies

S Tariq, P Kamboj, O Alam, M Amir - Bioorganic chemistry, 2018 - Elsevier
Abstract Novel N-(benzothiazol/oxazol-2-yl)-2-[(5-(phenoxymethyl)-4-aryl-4H-1, 2, 4-triazol-3-
yl) thio] acetamide derivatives (5a-n) were synthesized and investigated for in vitro anti …

Discovery of novel pyrimidine-based benzothiazole derivatives as potent cyclin-dependent kinase 2 inhibitors with anticancer activity

PC Diao, WY Lin, XE Jian, YH Li, WW You… - European Journal of …, 2019 - Elsevier
To develop novel CDK2 inhibitors as anticancer agents, a series of novel pyrimidine-based
benzothiazole derivatives were designed and synthesized. Initial biological evaluation …

Importance of fluorine in benzazole compounds

T Al-Harthy, W Zoghaib, R Abdel-Jalil - Molecules, 2020 - mdpi.com
Fluorine-containing heterocycles continue to receive considerable attention due to their
unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules …