Pericytes, attached to the surface of capillaries, play an important role in regulating local
blood flow. Using optogenetic tools and genetically encoded reporters in conjunction with …

The association between increased serum urate and hypertension has been a subject of
intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones …

Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that currently affects
36 million people worldwide with no effective treatment available. Development of AD …

Type 2 diabetes (T2D) is associated with multiple comorbidities, including diabetic
retinopathy (DR) and cognitive decline, and T2D patients have a significantly higher risk of …

Background Little is known about the relation between dietary intake and cerebral amyloid
accumulation in aging. Objective We assessed the association of dietary glycemic measures …

Alzheimer's disease (AD) is the most common cause of age-related neurodegeneration and
dementia, and there are no available treatments with proven disease-modifying actions. It is …

The loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the
accumulation of protein inclusions (Lewy bodies) are the pathological hallmarks of …

Dementia is a growing public health concern, with an estimated prevalence of 57 million
adults worldwide. Alzheimer's disease (AD) accounts for 60–80% of the cases. Clinical trials …

Background: Many publications have investigated the association between metal ions and
the risk of Alzheimer's disease (AD), but the results were ambiguous. Aims: The objective of …