Pharmacological properties of chalcones: a review of preclinical including molecular mechanisms and clinical evidence

B Salehi, C Quispe, I Chamkhi, N El Omari… - Frontiers in …, 2021 - frontiersin.org
Chalcones are among the leading bioactive flavonoids with a therapeutic potential
implicated to an array of bioactivities investigated by a series of preclinical and clinical …

Exploring pharmacological significance of chalcone scaffold: a review

NK Sahu, SS Balbhadra… - Current medicinal …, 2012 - ingentaconnect.com
Chalcones (1, 3-diaryl-2-propen-1-ones) and their heterocyclic analogues, belong to the
flavonoid family, which possess a number of interesting biological properties such as …

Trends in utilization of the pharmacological potential of chalcones

DI Batovska, IT Todorova - Current clinical pharmacology, 2010 - ingentaconnect.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are open chain flavonoids that are widely
biosynthesized in plants. They are important for the pigmentation of flowers and, hence, act …

Structure–activity relationship of antibacterial chalcones

HP Ávila, EFA Smânia, F Delle Monache… - Bioorganic & medicinal …, 2008 - Elsevier
The antibacterial activity of 31 chalcones was tested against bacterial strains, Bacillus
cereus ATCC 11778, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC …

Synthesis, molecular docking and antimicrobial activity of new fused pyrimidine and pyridine derivatives

MAA Radwan, MA Alshubramy, M Abdel-Motaal… - Bioorganic …, 2020 - Elsevier
Synthesis of some new heterocyclic ring systems incorporated pyrimidine and pyridine
moieties starting from 1-(furan-2-yl)-3-(thiophen-2-yl) chalcone was achieved. The structure …

Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation

K Liaras, A Geronikaki, J Glamočlija, A Ćirić… - Bioorganic & medicinal …, 2011 - Elsevier
As part of ongoing studies in developing new antimicrobials, we report the synthesis of a
new class of structurally novel derivatives, that incorporate two known bioactive structures a …

Synthesis and biological evaluation of chalcone derivatives (mini review)

S Nasir Abbas Bukhari, M Jasamai… - Mini reviews in …, 2012 - ingentaconnect.com
Chalcones are the principal precursors for the biosynthesis of flavonoids and isoflavonoids.
A three carbon α, β-unsaturated carbonyl system constitutes chalcones. Chalcones are the …

Antiviral and antimicrobial applications of chalcones and their derivatives: From nature to greener synthesis

MH Nematollahi, M Mehrabani, Y Hozhabri… - Heliyon, 2023 - cell.com
Chalcones and their derivatives have been widely studied due to their versatile
pharmacological and biological activities, such as anti-inflammatory, antibacterial, antiviral …

Chalcones as Versatile Synthons for the Synthesis of 5-and 6-membered Nitrogen Heterocycles

H MT Albuquerque, C MM Santos… - Current Organic …, 2014 - ingentaconnect.com
Chalcones belong to the flavonoid family which constitutes one of the major classes of
naturally occurring oxygen heterocyclic compounds. The α, β-unsaturated carbonyl system …

Review of methods and various catalysts used for chalcone synthesis

S Nasir Abbas Bukhari, M Jasamai… - Mini-Reviews in …, 2013 - ingentaconnect.com
Chalcones are the main precursors for the biosynthesis of flavonoids and isoflavonoids.
Chalcones comprise of a three carbon α, β-unsaturated carbonyl system. These are the …