Recent advancements, limitations, and future perspectives of the use of personalized medicine in treatment of colon cancer
Due to the heterogeneity of colon cancer, surgery, chemotherapy, and radiation are
ineffective in all cases. The genomic profile and biomarkers associated with the process are …
ineffective in all cases. The genomic profile and biomarkers associated with the process are …
[HTML][HTML] Towards a better understanding of light-glucose induced modifications on the structure and biological activity of formulated Nivolumab
E De Diana, E Rizzotto, I Inciardi, L Menilli… - International Journal of …, 2024 - Elsevier
In the last years, monoclonal antibodies (mAbs) have rapidly escalated as
biopharmaceuticals into cancer treatments, mainly for their target specificity accompanied by …
biopharmaceuticals into cancer treatments, mainly for their target specificity accompanied by …
[HTML][HTML] Synthesis and evaluation of amyloid beta peptide/Ruthenium III-based complex drugs as drug delivery and anticancer activity
R Senthil - Toxicology Reports, 2024 - Elsevier
The development and characterization of anticancer complex drugs (ACD), specifically
Amyloid Beta Peptide (ABP)-Ruthenium III (Ru III)-nivolumab (NB), were explored through …
Amyloid Beta Peptide (ABP)-Ruthenium III (Ru III)-nivolumab (NB), were explored through …
Comprehensive physicochemical and functional analysis of pembrolizumab based on controlled degradation studies: Impact on antigen–antibody binding
A Torrente-López, J Hermosilla… - European Journal of …, 2024 - Elsevier
Monoclonal antibodies-based medicines are widely used in the treatment of different
diseases. These medicines are very sensitive to exposure to different environmental …
diseases. These medicines are very sensitive to exposure to different environmental …
Site-Specific Structural Changes in Long-Term-Stressed Monoclonal Antibody Revealed with DEPC Covalent-Labeling and Quantitative Mass Spectrometry
M Gaikwad, F Richter, R Götz, A Dörrbaum… - Pharmaceuticals, 2023 - mdpi.com
Studies of structural changes in mAbs under forced stress and storage conditions are
essential for the recognition of degradation hotspots, which can be further remodeled to …
essential for the recognition of degradation hotspots, which can be further remodeled to …
[HTML][HTML] Development of a Mammalian Cell Line for Stable Production of Anti-PD-1
E Csató-Kovács, P Salamon, S Fikó-Lászlo, K Kovács… - Antibodies, 2024 - mdpi.com
Background/Objectives: Immune checkpoint blockade, particularly targeting the
programmed cell death 1 (PD-1) receptor, is a promising strategy in cancer immunotherapy …
programmed cell death 1 (PD-1) receptor, is a promising strategy in cancer immunotherapy …
[HTML][HTML] Comprehensive Analysis of Cetuximab Critical Quality Attributes: Impact of Handling on Antigen-Antibody Binding
A Torres-García, A Torrente-López, J Hermosilla… - Pharmaceutics, 2024 - mdpi.com
Background/Objectives: Cetuximab, formulated in Erbitux®(5 mg/mL), is a therapeutic
monoclonal antibody (mAb) widely used in several cancer treatments. Currently, there is …
monoclonal antibody (mAb) widely used in several cancer treatments. Currently, there is …
Characterization of therapeutic antibody charge heterogeneity under stress conditions by microfluidic capillary electrophoresis coupled with mass spectrometry
Z Wu, H Wang, X Zhao, C Gong, S Sidnam… - Journal of …, 2024 - Elsevier
Therapeutic antibodies are a major class of biopharmaceutics that are applied in disease
treatment because of their many advantages, including high specificity and high affinity to …
treatment because of their many advantages, including high specificity and high affinity to …
[HTML][HTML] Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one
ZY Zhao, PL Luo, X Guo, ZW Huang - World Journal of Diabetes, 2025 - wjgnet.com
Ma et al recently reported in the World Journal of Diabetes that ferroptosis occurs in
osteoblasts under high glucose conditions, reflecting diabetes pathology. This condition …
osteoblasts under high glucose conditions, reflecting diabetes pathology. This condition …
Development and biophysical characterization of a humanized FSH–blocking monoclonal antibody therapeutic formulated at an ultra-high concentration
Highly concentrated antibody formulations are oftentimes required for subcutaneous, self-
administered biologics. Here, we report the development of a unique formulation for our first …
administered biologics. Here, we report the development of a unique formulation for our first …