Decoding leader cells in collective cancer invasion
Collective cancer invasion with leader–follower organization is increasingly recognized as a
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …
The mechanics of fibrillar collagen extracellular matrix
B Sun - Cell Reports Physical Science, 2021 - cell.com
As a major component of the human body, the extracellular matrix (ECM) is a complex
biopolymer network. The ECM not only hosts a plethora of biochemical interactions but also …
biopolymer network. The ECM not only hosts a plethora of biochemical interactions but also …
Unravelling cell migration: defining movement from the cell surface
F Merino-Casallo, MJ Gomez-Benito… - Cell adhesion & …, 2022 - Taylor & Francis
Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …
The interface stiffness and topographic feature dictate interfacial invasiveness of cancer spheroids
During cancer metastasis, tumor cells likely navigate, in a collective manner, discrete tissue
spaces comprising inherently heterogeneous extracellular matrix microstructures where …
spaces comprising inherently heterogeneous extracellular matrix microstructures where …
Correlation between the Warburg effect and progression of triple-negative breast cancer
S Liu, Y Li, M Yuan, Q Song, M Liu - Frontiers in Oncology, 2023 - frontiersin.org
Triple-negative breast cancer (TNBC) is ineligible for hormonal therapy and Her-2-targeted
therapy due to the negative expression of the estrogen receptor, progesterone receptor, and …
therapy due to the negative expression of the estrogen receptor, progesterone receptor, and …
Microclaw Array Fabricated by Single Exposure of Femtosecond Airy Beam and Self-Assembly for Regulating Cell Migratory Plasticity
The highly aligned extracellular matrix of metastatic breast cancer cells is considered to be
the “highway” of cancer invasion, which strongly promotes the directional migration of …
the “highway” of cancer invasion, which strongly promotes the directional migration of …
Patterned photocrosslinking to establish stiffness anisotropies in fibrous 3D hydrogels
Cells are known to constantly interact with their local extracellular matrix (ECM) and respond
to a variety of biochemical and mechanical cues received from the ECM. Nonetheless …
to a variety of biochemical and mechanical cues received from the ECM. Nonetheless …
Coupling traction force patterns and actomyosin wave dynamics reveals mechanics of cell motion
Motile cells can use and switch between different modes of migration. Here, we use traction
force microscopy and fluorescent labeling of actin and myosin to quantify and correlate …
force microscopy and fluorescent labeling of actin and myosin to quantify and correlate …
[HTML][HTML] Pore size-mediated macrophage M1 to M2 transition affects osseointegration of 3D-printed PEEK scaffolds
X Yang, J Gao, S Yang, Y Wu, H Liu… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Increasing evidence indicates that macrophages play an important role in angiogenesis and
bone regeneration. Because the phenotypic polarization of macrophage is extremely …
bone regeneration. Because the phenotypic polarization of macrophage is extremely …
The ECM and tissue architecture are major determinants of early invasion mediated by E-cadherin dysfunction
S Melo, P Guerrero, M Moreira Soares… - Communications …, 2023 - nature.com
Germline mutations of E-cadherin cause Hereditary Diffuse Gastric Cancer (HDGC), a highly
invasive cancer syndrome characterised by the occurrence of diffuse-type gastric carcinoma …
invasive cancer syndrome characterised by the occurrence of diffuse-type gastric carcinoma …