Collective cancer invasion with leader–follower organization is increasingly recognized as a
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …

As a major component of the human body, the extracellular matrix (ECM) is a complex
biopolymer network. The ECM not only hosts a plethora of biochemical interactions but also …

Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

During cancer metastasis, tumor cells likely navigate, in a collective manner, discrete tissue
spaces comprising inherently heterogeneous extracellular matrix microstructures where …

Triple-negative breast cancer (TNBC) is ineligible for hormonal therapy and Her-2-targeted
therapy due to the negative expression of the estrogen receptor, progesterone receptor, and …

The highly aligned extracellular matrix of metastatic breast cancer cells is considered to be
the “highway” of cancer invasion, which strongly promotes the directional migration of …

Cells are known to constantly interact with their local extracellular matrix (ECM) and respond
to a variety of biochemical and mechanical cues received from the ECM. Nonetheless …

Motile cells can use and switch between different modes of migration. Here, we use traction
force microscopy and fluorescent labeling of actin and myosin to quantify and correlate …

Increasing evidence indicates that macrophages play an important role in angiogenesis and
bone regeneration. Because the phenotypic polarization of macrophage is extremely …

Germline mutations of E-cadherin cause Hereditary Diffuse Gastric Cancer (HDGC), a highly
invasive cancer syndrome characterised by the occurrence of diffuse-type gastric carcinoma …