Acute kidney injury (AKI) is a frequent complication of critical illness and carries a significant
risk of short-and long-term mortality, chronic kidney disease (CKD) and cardiovascular …

The acutely injured mammalian kidney mounts a cellular and molecular response to repair
itself. However, in patchy regions such intrinsic processes are impaired and dysregulated …

Renal tissue injury initiates inflammatory and fibrotic processes that occur to promote
regeneration and repair. After renal injury, damaged tissue releases cytokines and …

Increasing evidence has demonstrated the bidirectional link between acute kidney injury
(AKI) and chronic kidney disease (CKD) such that, in the clinical setting, the new concept of …

Chronic kidney disease (CKD), characterized by sustained inflammation and progressive
fibrosis, is highly prevalent and can eventually progress to end-stage kidney disease …

The proximal tubule epithelium relies on mitochondrial function for energy, rendering the
kidney highly susceptible to ischemic AKI. Dynamin-related protein 1 (DRP1), a mediator of …

Acute kidney injury (AKI) is a major clinical problem associated with increased morbidity and
mortality. Despite intensive research, the clinical outcome remains poor, and apart from …

Abstract Purpose of Review The goal of this review is to review the role that renal
parenchymal lipid accumulation plays in contributing to diabetic kidney disease (DKD) …

Fibrosis is the excessive deposition of extracellular matrix components, which results in
disruption of tissue architecture and loss of organ function. Fibrosis leads to high morbidity …

Acute kidney injury (AKI) is a common and serious disease entity that affects native kidneys
and allografts but for which no specific treatments exist. Complex intrarenal inflammatory …