Mutations in the transcriptional regulator, Aire, cause APECED, a polyglandular autoimmune
disease with monogenic transmission. Animal models of APECED have revealed that Aire …

About two decades ago, cloning of the autoimmune regulator (AIRE) gene materialized one
of the most important actors on the scene of self-tolerance. Thymic transcription of genes …

Aire induces the expression of a battery of peripheral-tissue self-antigens (PTAs) in thymic
stromal cells, promoting the clonal deletion of differentiating T cells that recognize them. Just …

The induction of central T cell tolerance in the thymus depends on the presentation of
peripheral self-epitopes by medullary thymic epithelial cells (mTECs). This promiscuous …

The role of the autoimmune regulator (Aire) in central immune tolerance and thymic self-
representation was first described more than 20 years ago, but fascinating new insights into …

Aire is a transcription factor that controls T cell tolerance by inducing the expression of a
large repertoire of genes specifically in thymic stromal cells. It interacts with scores of protein …

There has long been conceptual and experimental support for, but also challenges to, the
notion that the initial period of the immune system's development is particularly important for …

In the thymus, developing T cells that react against self-antigens with high affinity are
deleted in the process of negative selection. An essential component of this process is the …

Aire is a transcriptional regulator that induces expression of peripheral tissue antigens (PTA)
in thymic medullary epithelial cells (MECs), driving immunological self-tolerance in …

The establishment of central tolerance in the thymus is critical for avoiding deleterious
autoimmune diseases. Autoimmune regulator (AIRE), the causative gene in autoimmune …